生体摂取物微粒子の製造方法

Japanese Patent JP4419157

B2

A method of separating biologically ingestible microparticles is used to obtain biologically ingestible microparticles in a thin film fluid formed between two processing surfaces provided with a solution containing a first solvent in which an objective substance to be pulverized is dissolved and a solvent capable of serving as a second solvent in which the solubility of the microparticles is lower than in the first solvent, the two processing surfaces being arranged so as to be able to approach to and separate from each other, at least one of which rotates relative to the other. In the method for producing biologically ingestible microparticles by separating raw materials of biologically ingestible microparticles by a neutralization reaction in a fluid, the fluid is formed into a thin film fluid between two processing surfaces arranged so as to be able to approach to and separate from each other, at least one of which rotates relative to the other, and biologically ingestible microparticles are separated by a neutralization reaction in the thin film fluid. A solution containing a first solvent in which a chemical as a main eye drop component is dissolved, and a solvent capable of serving as a second solvent in which the solubility of the chemical is lower than in the first solvent, are mixed in a thin film fluid formed between two processing surfaces arranged so as to be able to approach to and separate from each other, at least one of which rotates relative to the other, thereby separating drug particles and providing suspended eye drops based on the drug particles.

Shinichi Enomura

JP2009503347A

February 24, 2010

July 04, 2008

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M Technique Co., Ltd.

A61K9/10; A61J3/00; A61K31/192; A61K31/436; A61K31/57; A61K31/58

JP2007077061A
JP2006028108A
JP2006089386A
JP2002538227A
JP2004174297A
JP2004049957A
JP2007230957A

Hiroyuki Okawa
Takenobu Samejima

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