Title:
ELISAアッセイを用いた循環する治療抗体、抗原および抗原/抗体複合体の測定
Document Type and Number:
Japanese Patent JP4424987
Kind Code:
B2
Abstract:
The present invention relates to a method of determining the efficacy of an antibody immunotherapy in a patient, the method comprising the step of detecting the level of circulating anti-CD52/CD52 complexes in a sample obtained from the patient previously, wherein the level of circulating anti-CD52/CD52 complexes is indicative of a reduction in the amount of therapeutic antibody reaching the target cells.
Inventors:
Arbita, maha
Keating, Michael Jay.
Manshali, Tagui
Keating, Michael Jay.
Manshali, Tagui
Application Number:
JP2003528839A
Publication Date:
March 03, 2010
Filing Date:
September 20, 2002
Export Citation:
Assignee:
BOARD OF REGENTS,THE UNIVERSITY OF TEXAS SYSTEM
International Classes:
G01N33/53; G01N33/564; A61K39/395; A61P5/14; A61P13/08; A61P13/10; A61P19/02; A61P25/00; A61P27/02; A61P35/00; A61P35/02; A61P37/02; A61P37/06; G01N33/543; G01N33/574; G01N33/577
Other References:
McLaughlin P. et al.,"Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program.",Journal of Clinical Oncology,米国,W. B. Saunders Company・The American Society of Clinical Oncology,1998年10月,Vol.16, No.8,P.2825-2533
Haisma H. J. et al.,"Antibody-antigen complex formation following injection of OC125 monoclonal antibody in patients with ovarian cancer.",International Journal of Cancer,Alan R. Liss, Inc,1987年12月15日,Vol.40,P.758-762
Sakahara H. et al.,"Effect of circulating antigen on immunoscintigraphy of ovarian cancer patients using anti-CA125 monoclonal antibody.",Japanese Journal of Cancer Research,日本,日本癌学会,1996年 6月30日,Vol.87, No.6,P.655-661
Haisma H. J. et al.,"Antibody-antigen complex formation following injection of OC125 monoclonal antibody in patients with ovarian cancer.",International Journal of Cancer,Alan R. Liss, Inc,1987年12月15日,Vol.40,P.758-762
Sakahara H. et al.,"Effect of circulating antigen on immunoscintigraphy of ovarian cancer patients using anti-CA125 monoclonal antibody.",Japanese Journal of Cancer Research,日本,日本癌学会,1996年 6月30日,Vol.87, No.6,P.655-661
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita