Title:
4-(6-ブロモヘキシルオキシ)-ブチルベンゼンの改良された製造方法
Document Type and Number:
Japanese Patent JP4424992
Kind Code:
B2
Abstract:
The invention relates to an improved method for producing 4-(6-bromohexyloxy) butylbenzene by reacting 4-phenylbutanol with 1,6-dibromohexane in the presence of a base and a phase transfer catalyst. 4-phenylbutanol is metered in a diluent to a mixture consisting of 1,6-dibromohexane, a base, a phase transfer catalyst, and a diluent. Also disclosed is the use of the resulting 4-(6-bromohexyloxy) butylbenzene for producing salmeterol in a previously known manner.
Inventors:
Heitger Helmut
Mayer Orifer
Mayer Orifer
Application Number:
JP2003572931A
Publication Date:
March 03, 2010
Filing Date:
February 28, 2003
Export Citation:
Assignee:
Boehringer Ingelheim Pharma Gesellshaft Mitt Beschlenktel Haftung Und Company Comandito Gesellshaft
International Classes:
C07C41/16; C07B61/00; C07C43/174
Domestic Patent References:
| JP59199659A | ||||
| JP2002525349A |
Other References:
Tadeusz F. MOLINSKI et al.,Journal of Labelled Compounds and Radiopharmaceuticals ,2002年,45(9),pp.755-762
Yajing RONG et al.,Synthetic Communications,1999年,29(12),pp.2155-2162
Yajing RONG et al.,Synthetic Communications,1999年,29(12),pp.2155-2162
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama