[1,2,4]-トリアゾール二環式アデノシンA2aレセプタアンタゴニスト

Japanese Patent JP4429724

B2

Compounds having the structural formula I wherein: n is 0, 1, 2 or 3; A is C(R¹) or N; R¹ and R^1a are H, (C₁-C₆)-alkyl, halo, CN or -CF₃; X is -C(O)-, -O-, -SO_0-2-, or optionally substituted methylene, imino, arylene or heteroaryldiyl; Y is -O-, -SO_0-2-, or optionally substituted arylene, heteroaryldiyl, or nitrogen-containing heterocycloalkyl, or with certain provisos, a bond; R is optionally substituted-aryl or heteroaryl; and R² is optionally substituted-aryl, heteroaryl, arylalkyl or heteroarylalkyl; or R²-Y is a fused piperidinyl, substituted piperazinyl or substituted piperidinyl; their use in the treatment of Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, pharmaceutical compositions comprising them and kits comprising the components of the combinations

JP7195027	Novel compound and pharmaceutical composition for enhancing anticancer activity containing the same
WO/2011/130481	PYRROLOPYRAZINONE INHIBITORS OF KINASES
WO/2022/207752	PHARMACEUTICAL COMPOUND

New Stud, Bernard Earl.
Riu, Hong

JP2003549353A

March 10, 2010

November 26, 2002

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Schering Corporation

C07D487/04; A61K31/519; A61P25/00; A61P25/16; A61P25/24; A61P25/28; C07D471/04

WO2001017999A1
WO1998042711A1
WO1999043678A1
WO1995003806A1
WO2000017201A1
US5356894

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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