Title:
2-オキサゾールアミンおよび5-HT2B受容体アンタゴニストとしてのその使用
Document Type and Number:
Japanese Patent JP4439266
Kind Code:
B2
Abstract:
The present invention relates to compounds of formula I: wherein one of R1 and R4 is selected from the group consisting of H, and optionally substituted C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, and phenyl-C1-4 alkyl; and the other of R1 and R4 is an optionally substituted C9-14 aryl group; R2 and R3 are either: (i) independently selected from H, R, R', SO2R, C(-O)R, (CH2)nNR5R6, where n is from 1 to 4 and R5 and R6 are independently selected from H and R, where R is optionally substituted C1-4 alkyl, and R' is optionally substituted phenyl-C1-4 alkyl, or (ii) together with the nitrogen atom to which they are attached, form an optionally substituted C5-7 heterocyclic group; and their use as pharmaceuticals, in particular for treating conditions alleviated by the antagonism of a 5-HT2B receptor.
Inventors:
Oxford, alexander, william
Bowman, Richard, Anthony
Coleman, Robert, Alexander
Clark, Kenneth, Lyle
Hind, George
Archer, janet, anne
Array, amanda
Harris, Nail, Victor
Bowman, Richard, Anthony
Coleman, Robert, Alexander
Clark, Kenneth, Lyle
Hind, George
Archer, janet, anne
Array, amanda
Harris, Nail, Victor
Application Number:
JP2003567408A
Publication Date:
March 24, 2010
Filing Date:
February 11, 2003
Export Citation:
Assignee:
Asterand UK Limited
International Classes:
C07D263/48; A61K31/421; A61K31/422; A61P1/00; A61P9/12; A61P13/08; A61P15/00; A61P25/00; A61P43/00; C07D413/04
Domestic Patent References:
| JP6211655A | ||||
| JP2000026313A | ||||
| JP7291936A | ||||
| JP2001525794A | ||||
| JP11193281A | ||||
| JP2001131161A | ||||
| JP7267964A |
Foreign References:
| WO2000023444A1 | ||||
| WO2000001675A1 | ||||
| WO1997003073A1 |
Other References:
MOLINA P,SYNTHESIS,1993年 1月,N1,P54-56
COOPER C S,JOURNAL OF MEDICINAL CHEMISTRY,1990年 4月,V33 N4,P1246-1252
BANSAL E,EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2001年 1月 1日,V36 N1,P81-92
Bansal, E.,Synthesis of some newer potent antiinflammatory substituted phenothiazines,Oriental Journal of Chemistry,1999年,15(3),p. 489-494
NATH J P,INDIAN JOURNAL OF CHEMISTRY, SECTION B,1981年 7月,V.20B, N.7,P606-607
PATTANAYAK B K,INDIAN JOURNAL OF CHEMISTRY, SECTION B,1978年11月,V.16B, N.11,P1030-1032
田中千秋,オキサゾールカルボン酸誘導体の合成(第8報) アミノオキサゾール類の還元的開裂について その2,薬学雑誌,1967年,87(1),p. 14-21
田中千秋,オキサゾールカルボン酸の合成(第9報) アルキル,アラルキル,あるいはアリル置換2-アミノオキサゾール類の合成,薬学雑誌,1971年,91(4),p. 425-435
COOPER C S,JOURNAL OF MEDICINAL CHEMISTRY,1990年 4月,V33 N4,P1246-1252
BANSAL E,EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2001年 1月 1日,V36 N1,P81-92
Bansal, E.,Synthesis of some newer potent antiinflammatory substituted phenothiazines,Oriental Journal of Chemistry,1999年,15(3),p. 489-494
NATH J P,INDIAN JOURNAL OF CHEMISTRY, SECTION B,1981年 7月,V.20B, N.7,P606-607
PATTANAYAK B K,INDIAN JOURNAL OF CHEMISTRY, SECTION B,1978年11月,V.16B, N.11,P1030-1032
田中千秋,オキサゾールカルボン酸誘導体の合成(第8報) アミノオキサゾール類の還元的開裂について その2,薬学雑誌,1967年,87(1),p. 14-21
田中千秋,オキサゾールカルボン酸の合成(第9報) アルキル,アラルキル,あるいはアリル置換2-アミノオキサゾール類の合成,薬学雑誌,1971年,91(4),p. 425-435
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Yuko Matsuniya
Ishii Teiji
Satoshi Fujita
Yuko Matsuniya