Title:
シンバスタチンの製造方法
Document Type and Number:
Japanese Patent JP4440476
Kind Code:
B2
Abstract:
This invention provides an easy and efficient process for producing a simvastatin of great use as an HMG-CoA reductase inhibitor, which comprises deacylation of lovastatin with an inorganic base and a secondary or tertiary alcohol and subjecting the resulting did lactone to selective protection with a ketal or acetal protective group, acylation and deprotection-lactonization to give simvastatin.
Inventors:
Naoaki Taoka
Kenji Inoue
Kenji Inoue
Application Number:
JP2000586711A
Publication Date:
March 24, 2010
Filing Date:
December 10, 1999
Export Citation:
Assignee:
Kaneka Corporation
International Classes:
C07D319/06; C07D309/30
Domestic Patent References:
| JP56122375A | ||||
| JP63068584A |
Foreign References:
| WO1998032751A1 |
Attorney, Agent or Firm:
Atomi International Patent Office
Yasuo Yasutomi
Shinya Furuya
Yasuo Yasutomi
Shinya Furuya