Title:
C型肝炎ウイルス阻害ペプチドアナログ
Document Type and Number:
Japanese Patent JP4452401
Kind Code:
B2
Abstract:
Compound of formula (I) active against the Hepatitis C virus: wherein B is an acyl derivative; a is 0 or 1; R6, when present, is carboxy(lower)alkyl; b is 0 or 1; R5, when present, is C1-6 alkyl, or carboxy (lower)alkyl; Y is H or C1-6 alkyl; R4 is C1-10 alkyl; R3 is C1-10 alkyl; W is -NH-CH(R2)-C(O)-, wherein R2 is C1-6 alkyl; C6 or C10 aryl; C7-16 aralkyl; or carboxy (lower)alkyl; or W is a proline derivative; Q is a group of the formula -Z(R1)-C(O)-R13, wherein Z is CH or N; R1 is C1-6 alkyl or C1-6 alkenyl both optionally substituted with thio or halo,; and R13 is an activated carbonyl substituent, or Q is a phosphonate group of the formula -CH(R1)-P(O)R15R16 wherein R15 and R16 are independently C6-20 aryloxy; and R1 is as defined above.
Inventors:
Rina Brune Monse
Bailey Murray Douglas
Harmos Teddy
Pupal Marc Andre
Zantoriso Yura
Bailey Murray Douglas
Harmos Teddy
Pupal Marc Andre
Zantoriso Yura
Application Number:
JP2000506236A
Publication Date:
April 21, 2010
Filing Date:
August 10, 1998
Export Citation:
Assignee:
Boehringer Ingelheim (Canada) Limited
International Classes:
A61K45/00; A61K31/13; C07K7/06; A61K31/7056; A61K38/00; A61K38/21; A61P31/14; C07K14/18
Domestic Patent References:
| JP5065230A | ||||
| JP4211697A |
Foreign References:
| WO1997027220A1 | ||||
| WO1998017679A1 | ||||
| WO1998022496A1 |
Other References:
Biochem. Biophys. Res. Commun. (Feb 1997) vol.231, no.3, p.738-742
Attorney, Agent or Firm:
Minoru Nakamura
Fumiaki Otsuka
Sadao Kumakura
Nobuo Ogawa
Takaki Nishijima
Atsushi Hakoda
Fumiaki Otsuka
Sadao Kumakura
Nobuo Ogawa
Takaki Nishijima
Atsushi Hakoda