Title:
光増感剤を用いて生物学的汚染物を不活化するための方法および装置
Document Type and Number:
Japanese Patent JP4464939
Kind Code:
B2
Abstract:
Methods and apparatuses are provided for inactivation of microorganisms in fluids or on surfaces. Preferably the fluids contain blood or blood products and comprise biologically active proteins. Preferred methods include the steps of adding an effective, non-toxic amount of an endogenous photosensitizer to a fluid and exposing the fluid to photoradiation sufficient to activate the endogenous photosensitizer whereby microorganisms are inactivated. Other fluids, including juices, water and the like, may also be decontaminated by these methods as may surfaces of foods, animal carcasses, wounds, food preparation surfaces and bathing and washing vessel surfaces. Alloxazines and K- and L- vitamins are among the preferred photosensitizers. Systems and apparatuses for flow-through and batch processes are also provided for decontamination of such fluids using photosensitizers.
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Inventors:
Goodrich, Raymond, Paul, Junior
Corbin, Frank, The Third
Wood, Edward, Sea, Junior
Flavinka, Dennis
Corbin, Frank, The Third
Wood, Edward, Sea, Junior
Flavinka, Dennis
Application Number:
JP2006182909A
Publication Date:
May 19, 2010
Filing Date:
July 03, 2006
Export Citation:
Assignee:
Kalidian BTC Biotechnology, LRC
International Classes:
A61K35/14; A61L2/02; A61L2/00; A61L2/08; A61L2/10; A61L2/16; A61L2/23; A61M1/36; A61L
Domestic Patent References:
| JP3500531A | ||||
| JP61275228A |
Other References:
UEHARA, K. et al,Effect of adenine on the riboflavin-sensitized photoreaction. II. Effect of adenine on the photodynamic inactivation of transforming deoxyribonucleic acid in the presence of riboflavin,THE JOURNAL OF BIOCHEMISTRY,1972年,vol.71, no.5, ,p.805-810
REINHARDT, A. et al,Virucidal activity of retinal,ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,1979年,vol.16, no.3,p.421-423
MURATA, A. et al,Effect of vitamins other than vitamin C on viruses: virus-inactivating activity of vitamin K5, JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY,1983年,vol.29, no.6,p.721-724
REINHARDT, A. et al,Virucidal activity of retinal,ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,1979年,vol.16, no.3,p.421-423
MURATA, A. et al,Effect of vitamins other than vitamin C on viruses: virus-inactivating activity of vitamin K5, JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY,1983年,vol.29, no.6,p.721-724
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Katsunori Ando
Kajiwara Saiko
Hajime Asamura
Katsunori Ando
Kajiwara Saiko