プロテインチロシンホスファターゼの細胞内ドメインに対する抗体

Title:

プロテインチロシンホスファターゼの細胞内ドメインに対する抗体

Document Type and Number:

Japanese Patent JP4469084

Kind Code:

B2

Abstract:

Antibodies to intracellular domains of two or more kinds of protein tyrosine phosphatases, methods for generation thereof and cells producing these antibodies are disclosed. The antibody of the present invention may have specificity to intracellular domains of phosphatase subunits of both of LAR and CD45, and may be useful for analysis and quantitative determination of PTPs, identification and detection of novel PTPs, and for obtaining novel phosphatases by cloning and the like, as well as for developing useful diagnostic methods of insulin resistance and NIDDM, for prophylaxis and diagnosis of various disease states of syndrome X that is based on insulin resistance, and for prophylaxis and diagnosis of onsets of arteriosclerosis and cardiac diseases.

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Inventors:

Hiroshi Yamamoto
Kazutake Tsujikawa
Yukiko Uchino

Application Number:

JP2000559151A

Publication Date:

May 26, 2010

Filing Date:

July 06, 1999

Export Citation:

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Assignee:

FUSO PHARMACEUTICAL INDUSTRIES,LTD.

International Classes:

C07K16/18; C07K16/40; C12N5/10; C12N5/20; C12N15/02; C12N15/06; C12P21/08; G01N33/53; G01N33/573; G01N33/577

Other References:

Proc.Natl.Acad.Sci.USA, 93[11](1996) p.5466-5471
J.Clin.Invest., 95(1995) p.2806-2812
TISSUE ANTIGENS, 42[4](1993) p.441(T073)

Attorney, Agent or Firm:

Yoshihiro Tsunoda

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