Title:
蛍光イオノホア化合物
Document Type and Number:
Japanese Patent JP4472795
Kind Code:
B2
Abstract:
A fluorescent ionophoric compound, comprising: a complexing moiety for selective binding of an ion; and a fluorescing moiety that contains close-lying n pi *and pi pi * excited states, wherein the compound has a wavelength of maximum absorbance of at least about 350 nm and a wavelength of maximum emission of no more than about 500 nm, wherein the compound is capable of ion dependent out-of-plane puckering and wherein the pi pi * state of the fluorescing moiety is sufficiently high in energy that ion dependent mixing dominates non-radiative coupling to the ground state. Especially a fluorescent ionophoric compound having the general formula: wherein: T is O or N, with the proviso that when T is O, q is 0 and n is 0 to 2, and when T is N, q is 1 and m and n are independently 0 or 1; each R<2> independently is a sterically non-interferring group; R<3> is selected from suitable electron withdrawing and non-electron withdrawing groups; R<1> is selected from suitable electron withdrawing and polarizable groups; and Z is O or NR<5>, where R<5> is hydrogen or a hydrocarbyl-containing group. The compound, which exhibits good photostability, can be incorporated into cation-sensing composite structures by means of convenient points of covalent attachment.
Inventors:
James G. Bensen
Kurt Jay Halberson
Xi Hyun Cho
John E. Trend
Elisa Em. Cross
Clay A Kipke
Masao Yafuso
Sanja El Patty
Kurt Jay Halberson
Xi Hyun Cho
John E. Trend
Elisa Em. Cross
Clay A Kipke
Masao Yafuso
Sanja El Patty
Application Number:
JP8914798A
Publication Date:
June 02, 2010
Filing Date:
February 27, 1998
Export Citation:
Assignee:
Terumo Cardiovascular Systems Corporation
International Classes:
C07D498/18; G01N21/64; C07D493/04; C09B23/10; G01N31/22; G01N33/20; G01N33/487
Domestic Patent References:
| JP61100599A | ||||
| JP2196777A | ||||
| JP7188248A | ||||
| JP2501481A |
Foreign References:
| US5136033 |
Other References:
TAKADATE, Akira et al.,"Synthesis and evaluation of novel crowned coumarins as self-catalytic fluorescence reagents",Bulletin of the Chemical Society of Japan,1995年,vol.68, no.11,p.3105-10
Attorney, Agent or Firm:
Takashi Ishida
Masaya Nishiyama
Jun Tsuruta
Higuchi Souji
Masaya Nishiyama
Jun Tsuruta
Higuchi Souji