Title:
酵素で切断可能な膜トランスロケーターを用いて改善されたペプチドの経口送達
Document Type and Number:
Japanese Patent JP4476544
Kind Code:
B2
Abstract:
Bioavailability of peptide active agents to be administered orally is enhanced by a pharmaceutical composition providing targeted release of the peptide to the intestine in addition to having the active peptide linked to a membrane translocator which is capable of being at least partially cleaved in vivo by an enzyme. The composition includes an acid-resistant protective vehicle which transports components of the invention through the stomach and a sufficient amount of a pH-lowering agent to lower local intestinal pH. All components are released together into the intestine with the peptide.
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Inventors:
William Stern
Nother M Mesa
Martha Vuel Rei
Nother M Mesa
Martha Vuel Rei
Application Number:
JP2002545737A
Publication Date:
June 09, 2010
Filing Date:
November 30, 2001
Export Citation:
Assignee:
Unigene Laboratories, Inc.
International Classes:
A61K47/48; A61K9/16; A61K9/48; A61K9/52; A61K38/00; A61K38/22; A61K38/23; A61K38/26; A61K38/28; A61K47/12; A61K47/14; A61K47/18; A61K47/24; A61K47/30; A61K47/42; A61K49/08; A61K49/10; A61K49/12; A61K49/14; A61K49/18; A61P3/08; A61P3/10; A61P3/14; A61P5/18; A61P5/48
Domestic Patent References:
| JP11508606A |
Foreign References:
| US5807746 |
Other References:
Science,Vol.285,pp.1569-1572,(1999)
Proc.Natl.Acad.Sci.,Vol.95,pp.9184-9189,(1998)
Nature Biotechnology,Vol.16,pp.440-443,(1998)
Nature Biotechnology,Vol.16,pp.370-375,(1998)
Proc.Natl.Acad.Sci.,Vol.95,pp.9184-9189,(1998)
Nature Biotechnology,Vol.16,pp.440-443,(1998)
Nature Biotechnology,Vol.16,pp.370-375,(1998)
Attorney, Agent or Firm:
Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro