カルバペネム化合物の製造方法 - Merck Sharp End Dome Corporation

Title:

カルバペネム化合物の製造方法

Document Type and Number:

Japanese Patent JP4480396

Kind Code:

B2

Abstract:

The present invention relates to a process for reducing the levels of organic solvents to pharmaceutically acceptable levels in thermally unstable crystalline carbapenem solids represented by formula I: or a salt thereof, wherein R₁and R₂, are the same or different, and are selected from H, alkyl, aryl, and heteroaryl, comprising washing a carbapenem solid containing organic solvent with an organic solvent containing water; and using vacuum and/or inert gas (hydrated or dry) at low temperature to produce a compound of formula I containing pharmaceutically acceptable levels of organic solvents, wherein the water content of the crystalline carbapenem solid, correcting for organic solvents, is maintained at about 13% to about 25% during the process.

Inventors:

Tubert Bitch, Raymond
Winslow, Robert
Williams, Jiyoung M
Danielle Seedrel
Crotker, Lewis
Tsun, Sien-Shin
Brian Kay, Ji Young Son
Kukula, Yosif The Second
Dee ring, wolf

Application Number:

JP2003530658A

Publication Date:

June 16, 2010

Filing Date:

September 20, 2002

Export Citation:

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Assignee:

Merck Sharp End Dome Corporation

International Classes:

C07D477/00; C07D487/04; C07D477/02; C07D477/20; A61K31/407; A61P31/04

Domestic Patent References:

JP64079180A
JP8012674A
JP2001072681A
JP9110869A
JP10195076A
JP8113573A
JP1268688A

Foreign References:

WO2000075143A1
WO1999045010A1

Other References:

実験化学講座(続)2 分離と精製,日本,丸善株式会社,1967年 1月25日,p.188
新実験化学講座1 基本操作I,日本,丸善株式会社,1975年 9月20日,p.322

Attorney, Agent or Firm:

Yoshio Kawaguchi
Makoto Ono
Katsuma Osaki

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