Title:
エストロン誘導体およびその製造方法
Document Type and Number:
Japanese Patent JP4481660
Kind Code:
B2
Abstract:
Estrone derivatives (I) are new. Estrone derivatives of formula (I) and their stereoisomers, hydrates, salts or ester are new. [Image] X 1, X 2H or (CH 2) mCH(COOH)(CH 2) nR 1; R 11-7C haloalkyl; R aOH; and R b2-5C alkynyl; or CR aR b= CO; m : 2-14; n : 2-7; and provided that X 1and X 2are not both H. ACTIVITY : Cytostatic; Osteopathic. In tests using ICR mice, administration of 10-(3-hydroxy-17-oxo-estra-1,3,5 (10)-trien-11beta -yl)-2-(4,4,5,5,6,6,7,7,7-nonafluoroheptyl)decanoic acid (Ia) at 10 mg/kg orally for 3 days inhibited 99% of estrogen activity. MECHANISM OF ACTION : Aromatase-Inhibitor; Anti-Estrogen.
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| WO/1996/034855 | FATTY ACID ESTERS AS BIOACTIVE COMPOUNDS |
Inventors:
Yoshiaki Nabuchi
Hiroshi Araya
Kawada snow
Kazumi Morikawa
Yoshitake Kannabe
Yoshihito Otake
Sea treasure Shinichi
Kenji Taniguchi
Toshiaki Hengsei
Takasu Nao
Hiroshi Araya
Kawada snow
Kazumi Morikawa
Yoshitake Kannabe
Yoshihito Otake
Sea treasure Shinichi
Kenji Taniguchi
Toshiaki Hengsei
Takasu Nao
Application Number:
JP2003584076A
Publication Date:
June 16, 2010
Filing Date:
April 02, 2003
Export Citation:
Assignee:
Chugai Pharmaceutical Co., Ltd.
International Classes:
C07J1/00; A61K31/566; A61P19/10; A61P35/00; A61P43/00; C07J9/00
Foreign References:
| WO2001042186A1 |
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takumi Terachi
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takumi Terachi