Title:
ヒトニューロン酸感受性陽イオンチャンネル、そのクローニング、および適用
Document Type and Number:
Japanese Patent JP4489952
Kind Code:
B2
Abstract:
Non inactivating or slowly inactivating proton-gated cation channels are thought to play an important role in the perception of pain that accompanies tissue acidosis. We have identified a novel human proton-gated cation channel subunit that has biphasic desensitisation kinetics with both a rapidly inactivating Na+-selective and a sustained component. The protein shares 84% sequence identity with the proton-gated cation channel rASIC3 (rDRASIC) from rat sensory neurones. The biphasic desensitisation kinetics and the sequence homology suggest that this novel clone (hASIC3) is the human orthologue of rASIC3 (rDRASIC). While rASIC3 (rDRASIC) requires very acidic pH (
Inventors:
Waldman Rainer
Basilena Frederick
Razo Dunski Mitchell
De Weile Jean Earl
Basilena Frederick
Razo Dunski Mitchell
De Weile Jean Earl
Application Number:
JP2000563774A
Publication Date:
June 23, 2010
Filing Date:
August 05, 1999
Export Citation:
Assignee:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE(CNRS)
International Classes:
C12N15/09; G01N33/50; C07K14/47; C07K14/705; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12Q1/02; G01N33/15; G01N33/68
Domestic Patent References:
| JP2001523113A |
Other References:
J Biol Chem., 272[47] (1997) p.29778-29783
J Biol Chem., 273[25] (1998 Jun) p.15418-15422
J Biol Chem., 274[15] (1999 Apr) p.10129-10132
FEBS Lett., 433 (1998. 8. 21) p.257-260
GenBank Acession No.AF095897 (1998. 10. 15)
J Biol Chem., 272[34] (1997) p.20975-20978
BBRC., 245[2] (1998 Apr) p.589-593
J Biol Chem., 273[25] (1998 Jun) p.15418-15422
J Biol Chem., 274[15] (1999 Apr) p.10129-10132
FEBS Lett., 433 (1998. 8. 21) p.257-260
GenBank Acession No.AF095897 (1998. 10. 15)
J Biol Chem., 272[34] (1997) p.20975-20978
BBRC., 245[2] (1998 Apr) p.589-593
Attorney, Agent or Firm:
Masago Onishi