Title:
薬物送達媒体としてのマルチアーム(multi-arm)ポリペプチド-ポリ(エチレングリコール)ブロックコポリマー
Document Type and Number:
Japanese Patent JP4490291
Kind Code:
B2
Abstract:
The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more) copolymer arms. Each copolymer arm possesses an inner polypeptide segment and an outer hydrophilic polymer segment. Thus, the overall structure of the copolymer comprises an inner core region that includes the central core and the inner polypeptide segment, while the outer core region is hydrophilic in nature. The multi-arm copolymer of the invention is particularly useful for delivery of biologically active agents that can be entrapped within the inner core region.
Inventors:
Ciao, Xuan S.
Ren, Jeonkyu
Huimoto Waho
Ren, Jeonkyu
Huimoto Waho
Application Number:
JP2004565733A
Publication Date:
June 23, 2010
Filing Date:
December 24, 2003
Export Citation:
Assignee:
Nectar Therapeutics Alabama, Corporation
International Classes:
C08G81/00; A61K9/51; A61K47/34; A61K47/42; A61K47/48; C08G65/329; C08L71/02
Domestic Patent References:
| JP9504308A | ||||
| JP2003520210A | ||||
| JP2003503569A |
Foreign References:
| WO2001049268A1 | ||||
| WO2001000709A1 |
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Tatsunori Ikeda
Masaya Nishiyama
Takashi Ishida
Fukumoto product
Tetsuji Koga
Tatsunori Ikeda
Masaya Nishiyama