Title:
含窒素芳香複素環化合物を含有するアルツハイマー病の予防薬若しくは治療薬又はアミロイド蛋白線維化抑制剤
Document Type and Number:
Japanese Patent JP4490690
Kind Code:
B2
Abstract:
The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R<1> and R<2> are H or alkyl; Z<1> and Z<2> are H, alkyl, alkoxy, haloalkyl or halogeno; Z<3> is alkoxy, SH, alkylthio, NH2, mono- or di-alkylamino, OH or halogeno; Z<4> and Z<5> are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).
More Like This:
Inventors:
Meguro Regular
Tomiichiro Oda
Yasuhiro Nakagami
Marumoto Masashi
Kazuo Koyama
Isao Kaneko
Tomiichiro Oda
Yasuhiro Nakagami
Marumoto Masashi
Kazuo Koyama
Isao Kaneko
Application Number:
JP2003547375A
Publication Date:
June 30, 2010
Filing Date:
November 25, 2002
Export Citation:
Assignee:
BTG International Limited
International Classes:
C07D237/20; A61K31/50; A61K31/505; A61K31/53; A61P3/10; A61P25/00; A61P25/28; A61P35/00; A61P43/00; C07D237/22; C07D239/48; C07D239/50; C07D241/20; C07D251/18; C07D251/48; C07D251/52; C07D251/70
Domestic Patent References:
| JP9506363A |
Foreign References:
| WO2000012485A1 | ||||
| WO1997019065A1 | ||||
| US2393755 | ||||
| WO2001025220A1 |
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Reiko Izumiya
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Reiko Izumiya