Title:
ジオキソランヌクレオシド類似体の立体選択的製造方法
Document Type and Number:
Japanese Patent JP4501135
Kind Code:
B2
Abstract:
The present invention relates to a process for producing compounds of formula (I) and (VII); said process comprising the steps of: a) subjecting a compound of formula (II) to an enzymatic diastereomeric resolution in the presence of a suitable amount of enzyme chosen from Pig Liver Esterase or Porcine Pancreatic Lipase b) recovering said compounds of formula (I) and (VII). The invention also provides a process for producing compounds of formula (III) and (X); said process comprising the steps of: a) subjecting a compound of formula (IV) to an enzymatic diastereomeric resolution in the presence of a suitable amount of enzyme chosen from Candida Antarctica “A” lipase, Candida Antarctica “B” lipase, Candida Lypolitica Lipase or Rhizomucor Miehei Lipase b) recovering said compound of formula (III) and (X).
Inventors:
Alex, Simpoia
La Ronde, James, Joseph
La Ronde, James, Joseph
Application Number:
JP2004554100A
Publication Date:
July 14, 2010
Filing Date:
November 18, 2003
Export Citation:
Assignee:
Share Canada Incorporated
International Classes:
C12P41/00; C07D317/32; C12P17/04; C12R1/645; C12R1/72; C12R1/73
Domestic Patent References:
| JP10147586A |
Foreign References:
| WO2000047759A1 |
Other References:
J Org Chem, (1992), vol.57, no.21, p.5563-5565
Attorney, Agent or Firm:
Calyx
Miyazaki Yoshio
Toshio Nakamura
Tsutomu Kato
Kaoru Onozuka
High Masahiro
Yusuke Murakoshi
Tomoaki Komiya
Miyazaki Yoshio
Toshio Nakamura
Tsutomu Kato
Kaoru Onozuka
High Masahiro
Yusuke Murakoshi
Tomoaki Komiya