Title:
ドラスタチン15誘導体
Document Type and Number:
Japanese Patent JP4508413
Kind Code:
B2
Abstract:
Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a β-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.
Inventors:
Janssen, Bernd
Barrotsari, Teresa
Haupt, Andreas
Tielke, Thomas
Cling, Andreas
Barrotsari, Teresa
Haupt, Andreas
Tielke, Thomas
Cling, Andreas
Application Number:
JP2000503101A
Publication Date:
July 21, 2010
Filing Date:
July 07, 1998
Export Citation:
Assignee:
ABBOTT LABORATORIES
International Classes:
A61K38/00; A61K38/08; C07K7/06; A61P35/00; C12P19/34
Foreign References:
| WO1993023424A1 | ||||
| WO1997017364A1 | ||||
| WO1997022621A1 | ||||
| WO1996040751A1 | ||||
| WO1996040752A1 |
Attorney, Agent or Firm:
Satoshi Eto