Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
セフェム化合物の製造方法
Document Type and Number:
Japanese Patent JP4510957
Kind Code:
B2
Abstract:
1. A process for preparing a 3-alkenylcephem compound or 3-norcephem compound of the formula (3) characterized in that an alkenyl halide of the formula (2), a nickel catalyst, a metal up to -0.3 (V/SCE) in standard oxidation reduction potential and a compound of a metal having a higher standard oxidation reduction potential than the metal are caused to act on a 3-cephem compound of the formula (1) in a solvent wherein R<1> is a hydrogen atom or the like, R<2> is a hydrogen atom or the like, R<3> is a hydrogen atom or carboxylic acid protective group, and X is a halogen atom or the like, R<4>-Y wherein R<4> is 1-alkenyl having or not having a substituent, and Y is a halogen atom wherein R<1>, R<2> and R<3> are as defined above, and R<5> is a hydrogen atom or 1-alkenyl having or not having a substituent.

Inventors:
Hideo Tanaka
Kameyama Yutaka
Application Number:
JP24727299A
Publication Date:
July 28, 2010
Filing Date:
September 01, 1999
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
Otsuka Chemical Co., Ltd.
International Classes:
C07D501/04; B01J31/30; C07B61/00; C07D501/00; C07D501/16; C07D501/22; C07D501/24
Domestic Patent References:
JP1224331A
JP47034387A
JP54003087A
JP3220195A
Other References:
田中 秀雄など,複合金属レドックスを電子移動触媒とするβ-ラクタム関連化合物の特異的変換,第16回エレクトロオーガニックケミストリー討論会講演要旨集,1994年,p.61-62
田中 秀雄など,セファロスポリンの開環/再閉環によるペナム、ペネム誘導体への変換,日本化学会第72春季年会-講演予稿集II,1997年 3月12日,p.1214
Hideo TANAKA et al,Construction of cephem framework via sequential reductive 1,2-elimination-hydride addition in a tributyltin hydride-copper(I) chloride-NMP system: synthesis of 3-norcephalosporin,CHEM. COMMUN.,1996年11月 7日,no.21,p.2705-2706
TANAKA,H. et al,Conversion of cephem into penam/penem through sequential ring-opening/recyclization in an Al/BiCl3/AlCl3 system,Chemistry Letters,1997年,no.12,p.1221-1222
田中 秀雄など,ペニシリン-セファロスポリン変換(27)ニッケル/鉛/アルミニウム複合レドックス系を用いる3-アリル、3-ベンジルセフェムの新規合成法,日本化学会第67春季年会-講演予稿集II,1994年 3月14日,p.1006
Hideo TANAKA et al,A Facile Access to 3-Allyl- and 3-Benzyl-3-cephems via Reductive Addition/Cyclization of Allenecarboxylate with Allyl and Benzyl Halides in an Al/Pb/Ni Redox System,J. CHEM. SOC., CHEM. COMMUN.,1994年 6月21日,no.12,p.1461-1462
Hideo TANAKA et al,Reductive dimerization of vinyl halides in an Ni/Pb/Al three metal redox system. A facile access to terphenyl derivatives,Tetrahedron Letters,1989年,vol.30, no.10,p.1261-1264
Attorney, Agent or Firm:
Iwao Tamura



 
Previous Patent: JPS4510956

Next Patent: JPS4510958