Title:
心不全治療剤
Document Type and Number:
Japanese Patent JP4534092
Kind Code:
B2
Abstract:
The present invention provides methods for screening drugs inhibiting the expression of OSF-2 gene or the production or function of the protein encoded thereby and therapeutic agents for heart failure having such effects. Useful methods for diagnosing heart failure can be provided by monitoring the expression or variation of said gene or the production of the protein encoded thereby. The present invention also provides transgenic animals with forced expression of OSF-2 gene and methods for studying changes in gene expression or protein production or the functions of various genes or proteins with the progress of the pathology of heart failure using them and novel therapeutic agents for heart failure.
Inventors:
Kashima Kayoko
Katsuragi Naruto
Keijiro Sugimura
Furuya Mayumi
Ryuichi Morishita
Katsuragi Naruto
Keijiro Sugimura
Furuya Mayumi
Ryuichi Morishita
Application Number:
JP2002524538A
Publication Date:
September 01, 2010
Filing Date:
September 07, 2001
Export Citation:
Assignee:
Daiichi Sankyo Co., Ltd.
International Classes:
A61K48/00; A61P9/02; A61P9/04; C07K14/47; C07K14/475; C12N15/12; A61K39/00
Domestic Patent References:
| JPH05268982A | 1993-10-19 | |||
| JPH07118156A | 1995-05-09 |
Foreign References:
| WO2000035473A2 | 2000-06-22 | |||
| WO1996019225A1 | 1996-06-27 |
Attorney, Agent or Firm:
Kazuo Shamoto
Kimiki Ishibashi
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Osamu Yamamoto
Kiyoshi Murakami
Kimiki Ishibashi
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Osamu Yamamoto
Kiyoshi Murakami