Title:
第VIII因子及び中性リポソームを含有する薬学的組成物
Document Type and Number:
Japanese Patent JP4545928
Kind Code:
B2
Abstract:
A pharmaceutical composition for parenteral administration comprising a therapeutically effective amount of a protein or polypeptide and substantially neutral colloidal particles. The particles comprise approximately 1-20 mole percent of an amphipathic lipid derivatized with a biocompatible hydrophilic polymer which carriers substantially no net charge. The protein or polypeptide is capable of externally binding the colloidal particles, or is capable of binding polyethylene glycol, and is not encapsulated in the colloidal particles. A preferred protein is factor VIII, whose half-life is extended and which is protected from serum inhibitor antibodies by injecting it as a component of the composition.
Inventors:
Bar, Moshe
Bar, liliana
Noua, Israel
Bar, liliana
Noua, Israel
Application Number:
JP2000545506A
Publication Date:
September 15, 2010
Filing Date:
April 23, 1999
Export Citation:
Assignee:
Zilip Pharma B.V.
International Classes:
A61K38/43; A61K9/127; A61K9/50; A61K38/37; A61K47/24; A61K47/34; A61P7/04
Domestic Patent References:
| JP56127307A |
Foreign References:
| US5013556 |
Other References:
Barrowcliffe, T.W. et al.,The Journal of laboratory and clinical medicine,1983年,Vol.101, No.1,pp.34-43
Blume, G. et al.,Biochimica et biophysica acta,1993年,Vol.1149, No.1,pp.180-184
Blume, G. et al.,Biochimica et biophysica acta,1993年,Vol.1149, No.1,pp.180-184
Attorney, Agent or Firm:
Takehiko Suzue
Kurata Masatoshi
Satoshi Kono
Makoto Nakamura
Yoshihiro Fukuhara
Takashi Mine
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Kocho Chojiro
Katsu Sunagawa
Katsumura Hiro
Kurata Masatoshi
Satoshi Kono
Makoto Nakamura
Yoshihiro Fukuhara
Takashi Mine
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Kocho Chojiro
Katsu Sunagawa
Katsumura Hiro