三次元印刷により製造されたゼロ次放出プロフィール投薬形態のような徐放投薬形態を製造するためのシステム

Title:

三次元印刷により製造されたゼロ次放出プロフィール投薬形態のような徐放投薬形態を製造するためのシステム

Document Type and Number:

Japanese Patent JP4551089

Kind Code:

B2

Abstract:

The present invention includes controlled release dosage forms and methods of designing and manufacturing dosage forms to obtain specific release profiles, for example, zero-order release profiles, escalating release profiles or decreasing release profiles. The dosage forms of the present invention can include spatial variation of API concentration in the dosage form and can include nested regions. Dosage forms according to the present invention may be manufactured by any appropriate method for obtaining the internal structure as disclosed herein for producing zero-order release profiles and increasing or decreasing release profiles. The invention further includes methods of manufacturing such dosage forms, such as by three-dimensional printing, possibly also including compression of the dosage form after three-dimensional printing. The invention further includes methods of designing such dosage forms. Release profiles from non-uniform distributions of API concentration may be predicted based on simple experiments with uniform-concentration dosage forms.

More Like This:

JP2022546496	Systems and methods for multi-drug delivery
WO/2004/096150	ORAL PHARMACEUTICAL DELIVERY SYSTEM WITH IMPROVED SUSTAINED RELEASE
JP4892351	Drug formulation containing a flavoring substance with improved drug properties

Inventors:

Price Lewis, Wendy E.
Rowie, Charles William
Cima, Michael Jay.
Matana, Peter A.

Application Number:

JP2003539591A

Publication Date:

September 22, 2010

Filing Date:

October 29, 2002

Export Citation:

Click for automatic bibliography generation Help

Assignee:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

International Classes:

A61K9/20; A61J3/10; A61K9/24; A61K9/28; A61K9/36; A61K9/44; A61K47/02; A61K47/26; A61K47/38

Domestic Patent References:

JP63239212A
JP2000507218A
JP2001501223A
JP62111923A
JP52083921A
JP59095214A
JP61000009A
JP9502999A
JP2001515472A
JP2003533470A

Foreign References:

WO2001037813A1
WO1998019668A1
GB793808B
US3184386
WO1993005769A1
EP0094123A1

Other References:

KATSTRA W E,JOURNAL OF CONTROLLED RELEASE,NL,ELSEVIER SCIENCE PUBLISHERS B.V.,2000年 5月,V66 N1,P1-9
ROWE C W,JOURNAL OF CONTROLLED RELEASE,NL,ELSEVIER SCIENCE PUBLISHERS B.V.,2000年 5月,V66 N1,P11-17

Attorney, Agent or Firm:

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

Previous Patent: 薄型心臓弁縫合リング

Next Patent: 脂肪組織の超音波処理および画像化