Title:
生物材料の化学洗浄
Document Type and Number:
Japanese Patent JP4558107
Kind Code:
B2
Abstract:
The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.
Inventors:
Abraham, Ginger, A.
Carr, Robert, M., Junior.
Kemp, Paul, Dee.
Masha, Ryan.
Baker, Linda.
Carr, Robert, M., Junior.
Kemp, Paul, Dee.
Masha, Ryan.
Baker, Linda.
Application Number:
JP54853698A
Publication Date:
October 06, 2010
Filing Date:
May 08, 1998
Export Citation:
Assignee:
ORGANOGENESIS INC.
International Classes:
A61F13/00; A01N1/02; C07K1/14; A61F2/00; A61F2/02; A61F2/06; A61F2/24; A61F2/28; A61K35/12; A61L27/24; A61L27/36; C12N5/08
Domestic Patent References:
| JP9502372A | ||||
| JP891814A | ||||
| JP8175984A | ||||
| JP535284U | ||||
| JP263462A |
Foreign References:
| WO1996008213A1 | ||||
| WO1995018529A1 | ||||
| WO1996009028A1 |
Other References:
人工臓器,Vol.26,No.1,1997,p.219-224
J.Clin.Invest.,Vol.86,1990,p.356-362
CancerRes.,Vol.55,1995,p.5101-5105
日皮会誌,93(11),1983,p.1237-1240
J.Clin.Invest.,Vol.86,1990,p.356-362
CancerRes.,Vol.55,1995,p.5101-5105
日皮会誌,93(11),1983,p.1237-1240
Attorney, Agent or Firm:
Shigeyoshi
Fukamachi Miko
Yoshikazu Tani
Kazuo Abe
Fukamachi Miko
Yoshikazu Tani
Kazuo Abe