Title:
トリメチルヒドロキノンジアルカノエートの製造方法
Document Type and Number:
Japanese Patent JP4558742
Kind Code:
B2
Abstract:
The present invention is directed to a process for the manufacture of a 2,3,5-trimethylhydroquinone dialkanoate comprising reacting ketoisophorone with an acylating agent in the presence of an indium salt as the catalyst. Preferred are indium(III) salts such as indium trichloride or indium tris (trifluoromethanesulfonate). Further aspects of the present invention are a process for the manufacture of 2,3,5-trimethylhydroquinone using 2,3,5-trimethylhydroquinone dialkanoate as the starting material, especially a process for the manufacture of 2,3,5-trimethylhydroquinone by transesterification of 2,3,5-trimethylhydroquinone dialkanoate, as well as a process for the manufacture of a-tocopherol and its alkanoates, especially of (all-rac)-a-tocopherol and its acetate, comprising the reaction of ketoisophorone to 2,3,5-trimethylhydroquinone dialkanoate according to the present invention. Furthermore, the present invention also deals with a process for the manufacture of formulations of a-tocopherol and its alkanoates, especially of formulations of (all-rac)-a-tocopherol and its acetate, comprising the reaction of ketoisophorone to 2,3,5-trimethylhydroquinone dialkanoate according to the present invention.
Inventors:
Bonras, Werner
Foricher, Yang
Foricher, Yang
Application Number:
JP2006544280A
Publication Date:
October 06, 2010
Filing Date:
December 07, 2004
Export Citation:
Assignee:
DSM IP ASSETS B.V.
International Classes:
C07C67/00; C07C37/01; C07C39/08; C07C67/40; C07C69/017; C07C69/16; C07D311/72; C07B61/00
Domestic Patent References:
| JP11140019A | ||||
| JP10237020A | ||||
| JP2003530377A |
Foreign References:
| WO2003051812A1 |
Other References:
A. K. CHAKRABORTI,TETRAHEDRON LETTERS,2003年,V44,P6749-6753
C. G. FROST,SYNLETT.,1999年,N11,P1743-1744
C. G. FROST,SYNLETT.,1999年,N11,P1743-1744
Attorney, Agent or Firm:
Yuichi Yamada
Masakazu Noda
Yoshinori Shimizu
Masakazu Noda
Yoshinori Shimizu