Title:
マクロファージの活性化を調節する方法
Document Type and Number:
Japanese Patent JP4574845
Kind Code:
B2
Abstract:
Anionic compounds, including sulfonates, are capable of blocking A beta -induced macrophage activation (or macrophage activation induced by other amyloidogenic proteins or peptides). Such compounds can inhibit the inflammatory process, e.g., in the brain of a subject suffering from a disease characterized by A beta deposition, such as Alzheimer's disease.
Inventors:
Morissette Celine
Gerve francine
Gerve francine
Application Number:
JP2000531161A
Publication Date:
November 04, 2010
Filing Date:
February 11, 1999
Export Citation:
Assignee:
BELLUS HEALTH(INTERNATIONAL) LIMITED
International Classes:
A61K31/255; A61K31/00; C12N5/10; A61K31/185; A61K31/381; A61K31/404; A61K31/495; A61K31/5375; A61K31/662; A61K45/00; A61K47/48; A61P25/28; A61P29/00; A61P37/02
Foreign References:
| WO1996028187A1 | ||||
| US5276059 | ||||
| WO1994022437A1 |
Other References:
KISILEVSKY R,ARRESTING AMYLOIDOSIS IN VIVO USING SMALL-MOLECULE ANIONIC SULPHONATES 以下備考,NATURE MEDICINE,1995年 2月 1日,V1N2,P143-148,OR SULPHATES: IMPLICATIONS FOR ALZHEIMER'S DISEASE
Attorney, Agent or Firm:
Tsutomu Kanakubo