Title:
分析対象物を検出する非侵襲性経皮システム
Document Type and Number:
Japanese Patent JP4584338
Kind Code:
B2
Abstract:
The present invention relates to noninvasive transdermal systems and methods for analyte extraction from a biological fluid within or beneath the skin, such as interstitial fluid, and detection of the analyte. More particularly, the present invention relates to noninvasive transdermal patches comprised of a wet chemistry component and a dry chemistry component. The wet chemistry component is a liquid transfer medium in the form of a gel layer for the extraction and liquid bridge transfer of the analyte of interest from the biological fluid within or beneath the skin to the dry chemistry component. The dry chemistry component is a super sensitive or conditioned membrane carrying a reagent system for interacting with the analyte of interest to generate an indicator molecule, e.g., color change, to confirm detection of the analyte, and methods of use thereof. The indicator molecule may be visually observed by the individual user or observed by an electronic interpretation component, such as a reflectance spectrophotometer for detection. A particular analyte of interest which may be detected accurately, reliably and quantitatively in accordance with the present invention is glucose. The noninvasive transdermal systems of the present invention are low in-cost and suitable for convenient use by non-medical personnel.
Inventors:
Aronowitz Jack El.
Mitchen, Joel, Earl
Mitchen, Joel, Earl
Application Number:
JP2009037281A
Publication Date:
November 17, 2010
Filing Date:
February 20, 2009
Export Citation:
Assignee:
Aronowitz Jack El.
International Classes:
A61B5/157; G01N33/48; A61B5/00; A61B5/145; A61B5/1455; G01N21/78; G01N33/52; G01N33/66; G01N33/94; A61B10/00
Domestic Patent References:
| JP63500427A | ||||
| JP1163666A | ||||
| JP63500396A |
Other References:
International Journal of Pharmaceutics,1995年,vol.117,p.219-224
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Toshi Gobe
Koichi Niimi