Title:
経口ワクチン組成物
Document Type and Number:
Japanese Patent JP4601823
Kind Code:
B2
Abstract:
Oral vaccine formulations are disclosed having microparticles sized such that at least 50% of the microparticles are less than 5 µm, preferably less than 3 µm, the microparticles containing antigen entrapped or encapsulated, such as by a solvent evaporation method, by a biodegradable polymer, such as poly (D,L-lactide-co-glycolide). Additionally, oral vaccine formulations are disclosed having nanoparticles sized such that at least 50% of the microparticles are less than 600nm, preferably less than 500nm, the nanoparticles containing antigen entrapped or encapsulated, such as by a coacervation method, by a biodegradable polymer, such as poly (D,L-lactide-co-glycolide). Protective vaccine formulations containing the B. pertussis antigens PTd or a combination of PTd and FHA are provided.
Inventors:
Braiden, David James
Application Number:
JP2000567236A
Publication Date:
December 22, 2010
Filing Date:
August 31, 1999
Export Citation:
Assignee:
Merrion Research III Limited
International Classes:
A61K9/50; A61K39/00; A61K9/00; A61K9/16; A61K9/51; A61K39/10; A61K47/34; A61P31/04; A61P37/04
Domestic Patent References:
| JP8009980A | ||||
| JP5503936A | ||||
| JP64034925A |
Foreign References:
| WO1996020698A1 |
Other References:
Infect. Immun.,1996年,Vol.64,pp.489-94
Vaccine,1995年,Vol.13,pp.455-62
Pharm. Res.,1996年,Vol.13,pp.1838-45
Vaccine,1995年,Vol.13,pp.455-62
Pharm. Res.,1996年,Vol.13,pp.1838-45
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita