Title:
L2ペプチドを含むキメラ・ヒト・パピローマウイルス16L1タンパク質、それから調製したウイルス様粒子および該粒子の調製方法
Document Type and Number:
Japanese Patent JP4614765
Kind Code:
B2
Abstract:
A method for producing a chimaeric human papillomavirus (HPV) L1 polypeptide containing a heterologous peptide, and in particular, a HPV L2 peptide comprising the steps of introducing a DNA sequence coding for the heterologous peptide into a DNA sequence coding for the L1 polypeptide; introducing the DNA sequence including the sequences for the L1 polypeptide and heterologous peptide into a host cell in which the DNA sequence can be expressed; causing expression of the DNA sequence; and recovering the resulting chimaeric L1 polypeptide which includes the heterologous peptide. The invention also describes a vector for use in the method, a host cell containing the vector, and a vaccine including the chimaeric HPV L1 polypeptide produced according to the method.
Inventors:
Arbind Debushi Versani
Edward Peter Ribiki
Edward Peter Ribiki
Application Number:
JP2004506346A
Publication Date:
January 19, 2011
Filing Date:
May 19, 2003
Export Citation:
Assignee:
UNIVERSITY OF CAPE TOWN
International Classes:
C12N15/09; A61K39/12; A61P31/20; C07K14/01; C07K14/025; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/37; C12P21/02
Domestic Patent References:
| JP11504801A |
Other References:
MUELLER M,VIROLOGY,米国,1997年 7月21日,V234 N1,P93-111
SLUPETZKY K,THE JOURNAL OF GENERAL VIROLOGY,英国,2001年11月,V82, N.PT.11,P2799-2804
KAWANA Y,JOURNAL OF VIROLOGY,米国,2001年 3月,V75 N5,P2331-2336
KAWANA Y,JOURNAL OF VIROLOGY,米国,1999年 7月,V73 N7,P6188-6190
SUN X Y,VIROLOGY,米国,1995年11月10日,V213 N2,P321-327
Virology,2001年,Vol.291,p.324-334
SLUPETZKY K,THE JOURNAL OF GENERAL VIROLOGY,英国,2001年11月,V82, N.PT.11,P2799-2804
KAWANA Y,JOURNAL OF VIROLOGY,米国,2001年 3月,V75 N5,P2331-2336
KAWANA Y,JOURNAL OF VIROLOGY,米国,1999年 7月,V73 N7,P6188-6190
SUN X Y,VIROLOGY,米国,1995年11月10日,V213 N2,P321-327
Virology,2001年,Vol.291,p.324-334
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Tsuyoshi Sato
Masaki Yano
Hiroshi Yamazaki
Tsuyoshi Sato
Masaki Yano