Title:
CPGおよびサポニンアジュバントの組成物並びにその方法
Document Type and Number:
Japanese Patent JP4620251
Kind Code:
B2
Abstract:
Vaccine compositions of immunostimulatory oligonucleotides and saponin adjuvants and antigens and the use thereof for stimulating immunity, enhancing cell-mediated immunity, and enhancing antibody production are disclosed. Also described are immune adjuvant compositions comprising immunostimulatory oligonucleotides and saponin adjuvants, as well as methods for increasing an immune response using the same.
Inventors:
Charlotte A Kencil
Application Number:
JP2000564661A
Publication Date:
January 26, 2011
Filing Date:
August 06, 1999
Export Citation:
Assignee:
ANTIGENICS INC.
International Classes:
A61K39/39; C12N15/09; A61K39/00; A61P37/04
Domestic Patent References:
| JP10506265A |
Foreign References:
| WO1998018810A1 |
Other References:
CHU, R.S., et al.,CpG Oligodeoxynucleotides Acts as Adjuvants that Switch on T Helper 1 (Th1) Immunity,Journal of Experimental Medicine,1997年11月17日,Vol.186, No.10,p.1623-1631
DAVIS, H.L., et al.,CpG DNA Is a Potent Enhancer of Specific Immunity in Mice Immunized with Recombinant Hepatitis B Surface Antigen,The Journal of Immunology,1998年 1月15日,Vol.160, No.2,p.870-876
WEINER, G.J., et al.,Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization,Proceedings of the National Academy of Sciences of the United States of America,1997年 9月30日,Vol.94, No.20,p.10833-10837
KLINMAN, D.M.,Therapeutic Applications of CpG-Containing Oligodeoxynucleotides,ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT,1998年 4月,Vol.8, No.2,p.181-184
KRIEG, A.M., et al.,The role of CpG dinucleotides in DNA vaccines,TRENDS IN MICROBIOLOGY,1998年 1月,Vol.6, No.1,p.23-27
SO, H-S., et al.,Effect of a Novel Saponin Adjuvant Derived from Quillaja saponaria on the Immune Response to Recombinant Hepatitis B Surface Antigen,Molecules and Cells,1997年 4月30日,Vol.7, No.2,p.178-186
KENSIL, C.R.,Saponins as Vaccine Adjuvants,Critical Reviews in Therapeutic Drug Carrier Systems,1996年,Vol.13, No.1&2,p.1-55
DAVIS, H.L., et al.,CpG DNA Is a Potent Enhancer of Specific Immunity in Mice Immunized with Recombinant Hepatitis B Surface Antigen,The Journal of Immunology,1998年 1月15日,Vol.160, No.2,p.870-876
WEINER, G.J., et al.,Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization,Proceedings of the National Academy of Sciences of the United States of America,1997年 9月30日,Vol.94, No.20,p.10833-10837
KLINMAN, D.M.,Therapeutic Applications of CpG-Containing Oligodeoxynucleotides,ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT,1998年 4月,Vol.8, No.2,p.181-184
KRIEG, A.M., et al.,The role of CpG dinucleotides in DNA vaccines,TRENDS IN MICROBIOLOGY,1998年 1月,Vol.6, No.1,p.23-27
SO, H-S., et al.,Effect of a Novel Saponin Adjuvant Derived from Quillaja saponaria on the Immune Response to Recombinant Hepatitis B Surface Antigen,Molecules and Cells,1997年 4月30日,Vol.7, No.2,p.178-186
KENSIL, C.R.,Saponins as Vaccine Adjuvants,Critical Reviews in Therapeutic Drug Carrier Systems,1996年,Vol.13, No.1&2,p.1-55
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Michiko Matsutani
Mina Shiga
Sakurai Yoko
Satoshi Hashimoto
Aoyama Aoi
Mitsutaka Iwasaki
Hiroshi Yamazaki
Michiko Matsutani
Mina Shiga
Sakurai Yoko
Satoshi Hashimoto
Aoyama Aoi
Mitsutaka Iwasaki