Title:
アントラキノンとその誘導体
Document Type and Number:
Japanese Patent JP4629871
Kind Code:
B2
Abstract:
There is disclosed a compound of formula (I) wherein each of X1 and X2 are independently NH-A-NR1R2, and wherein A is A C2-8 alkylene and R1 and R2 are independently selected from hydrogen, C1-4 alkyl, C2-4 hydroxy-alkyl and C2-4 aminoalkyl, or R1 and R2 together form a C2-6 alkylene group which with the nitrogen atom to which R1 and R2 are attached forms a heterocyclic ring, or an N-oxide derivative thereof, and wherein the compound (I) or its N-oxide derivative is optionally in the form of an acid salt derived from an organic or inorganic acid. Also disclosed is a method of its production and its uses, including its use in analyzing a cell or biological material and detecting the emitted fluorescence signal.
Inventors:
Smith, paul, james
Patterson, Lawrence, Hilton
Patterson, Lawrence, Hilton
Application Number:
JP2000554804A
Publication Date:
February 09, 2011
Filing Date:
June 15, 1999
Export Citation:
Assignee:
Bio Status Limited
International Classes:
C07C225/36; C09B1/515; C07D295/12; G01N21/78; C07H21/04; C09K11/06; C12N15/09; C12Q1/68; G01N33/52
Domestic Patent References:
| JP4502166A | ||||
| JP63250397A |
Other References:
Islam, Suhail A., et al.,Comparative computer graphics and solution studies of the DNA interaction of substituted anthraquinones based on doxorubicin and mitoxantrone,Journal of Medicinal Chemistry,1985年,Vol.28, No.7,p.857-64
Smith, Paul J., et al.,A novel cell permeant and far red-fluorescing DNA probe, DRAQ5, for blood cell discrimination by flow cytometry,Journal of Immunological Methods,1999年,Vol.229, No.1-2,p.131-139
Johnson, Randall K., et al.,Experimental antitumor activity of aminoanthraquinones,Cancer Treatment Reports,1979年,Vol.63, No.3,p.425-39
Smith, Paul J., et al.,Flow-cytometric analysis and confocal imaging of anticancer alkylaminoanthraquinones and their N-oxides in intact human cells by 647-nm krypton laser excitation,Cytometry,1997年,vol.27, No.1,p.43-53
Smith, Paul J., et al.,A novel cell permeant and far red-fluorescing DNA probe, DRAQ5, for blood cell discrimination by flow cytometry,Journal of Immunological Methods,1999年,Vol.229, No.1-2,p.131-139
Johnson, Randall K., et al.,Experimental antitumor activity of aminoanthraquinones,Cancer Treatment Reports,1979年,Vol.63, No.3,p.425-39
Smith, Paul J., et al.,Flow-cytometric analysis and confocal imaging of anticancer alkylaminoanthraquinones and their N-oxides in intact human cells by 647-nm krypton laser excitation,Cytometry,1997年,vol.27, No.1,p.43-53
Attorney, Agent or Firm:
Masayuki Kishida
Mizuno Katsufumi
Hiroshin Takano
Atsushi Mizumoto
Mizuno Katsufumi
Hiroshin Takano
Atsushi Mizumoto