Title:
抗ラクトンシグナル分子抗体または抗ラクトン由来シグナル分子抗体による感染性細菌症の治療のための方法
Document Type and Number:
Japanese Patent JP4630663
Kind Code:
B2
Abstract:
The present invention relates to methods for the control of virulence of infectious bacteria by modulating the extra-cellular concentration of bacterial cell signalling molecules. Derivatives of cell signalling molecules are conjugated to suitable carrier proteins and used to isolate high affinity receptors recognising the native signal molecule(s). By binding to signalling molecules, the receptors reduce and maintain extra-cellular concentrations of signal molecules below the threshold level that would otherwise result in certain opportunistic pathogens adopting a virulent form, and can transform virulent organisms to non-virulent states. These receptors have applications for the treatment of individuals with susceptibility to infection, the treatment of patients with existing infections, in disease monitoring and management, and in related applications where the host for infection is an animal or plant.
Inventors:
Charlton Keith Alan
Porter Andrew Justin Radcliffe
Porter Andrew Justin Radcliffe
Application Number:
JP2004527070A
Publication Date:
February 09, 2011
Filing Date:
August 13, 2003
Export Citation:
Assignee:
Haptogen Limited
International Classes:
C07K16/12; A61P31/04; C07K16/44; C12N15/09; G01N33/577; C07D307/33; C12P21/08
Foreign References:
| WO2001094543A1 | ||||
| WO1992001047A1 |
Other References:
Bioorganic and medicinal chemistry letters,2002年 4月,Vol.12,p.1153-1157
PNAS,1999年,Vol.96,p.1218-1223
Nature,2002年 1月,Vol.415,p.545-549
Microbiology,2000年,Vol.146,p.2481-2493
PNAS,1999年,Vol.96,p.1218-1223
Nature,2002年 1月,Vol.415,p.545-549
Microbiology,2000年,Vol.146,p.2481-2493
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Kazuya Kawamoto
Toshi Gobe
Koichi Niimi
Kazuya Kawamoto