Title:
心的外傷後ストレス障害、強迫性障害および関連する神経精神医学的障害の処置
Document Type and Number:
Japanese Patent JP4633262
Kind Code:
B2
Abstract:
The present invention describes a novel treatment for neuropsychiatric disorders, including anxiety disorders, mood disorders, psychotic disorders, somatoform disorders, and neuropsychiatric symptoms resulting from movement disorders. The treatment of the present invention utilizes any agent that simultaneously act as NMDA-type glutamate receptor antagonists and GABA-A receptor agonists. Preferably these two activities are characteristic of a single agent, for example acamprosate (calcium N-acetylhomotaurinate). Alternatively, separate agents having these activities can be combined as a compound or mixture and thereby administered together. The invention also provides for a third agent that acts as a non-competitive NMDA-receptor blocking agent or ion channel blocker, that augments the effect of the primary treatment. A particularly preferred ion channel blocking agent is magnesium.
Inventors:
Fogel, Barry S.
Application Number:
JP2000606206A
Publication Date:
February 16, 2011
Filing Date:
March 17, 2000
Export Citation:
Assignee:
Synchronized Ron, El Elsi-
International Classes:
A61K9/08; A61K31/255; A61K9/10; A61K9/20; A61K9/52; A61K9/70; A61K31/00; A61K31/13; A61K31/185; A61K45/00; A61K45/06; A61P25/14; A61P25/18; A61P25/22; A61P25/24; A61P43/00
Other References:
Medicinal Research Reviews,1985年,Vol.5, No.1,p.55-75
BIOL PSYCHIATRY,1997年,Vol.41,p.988-990
Meth and Find Exptl Clin Pharmacol,1988年,Vol.10, No.5,p.311-317
Br. J. Pharmac.,1984年,Vol.83,p.195-202
BIOL PSYCHIATRY,1997年,Vol.41,p.988-990
Meth and Find Exptl Clin Pharmacol,1988年,Vol.10, No.5,p.311-317
Br. J. Pharmac.,1984年,Vol.83,p.195-202
Attorney, Agent or Firm:
Hidesaku Yamamoto