Title:
ハロゲン化ローダミン誘導体およびその適用
Document Type and Number:
Japanese Patent JP4647187
Kind Code:
B2
Abstract:
Novel compounds of the formula (I) wherein: one of R1, R2, R3, R4, and (R10)n represents an halogen atom and each of the remaining R1, R2, R3, R4, and each of the remaining R10 group is independently selected in the group constituted by hydrogen, halogen atoms, an amino, acylamino, dialkylamino, cycloalkylamino, azacycloalkyl, alkylcycloalkylamino, aroylamino, diarylamino, arylalkylamino, aralkylamino, alkylaralkylamino, arylaralkylamino, hydroxy, alkoxy, aryloxy, aralkyloxy, mercapto, alkylthio, arylthio, aralkylthio, carboxyl, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, cyano, hydroxysulfonyl, amidosulfonyl, dialkylamidosulfonyl, arylalkylamidosulfonyl, formyl, acyl, aroyl, alkyl, alkylene, alkenyl, aryl, aralkyl, vinyl, alkynyl group and by the corresponding substituted groups; - m = 0 - 1; n = 1-4, A is nil, O, or NH; R9 represents an alkylene group; -Z is H, amino, dialkylamino, or trialkylamino salt; X- is an anion; R5, R6, R7 and R8 are independently H or C1-C6 alkyl or R1 in combination with R5 or R6, or R2 in combination with R5 or R6, or R3 in combination with R7 or R8, or R4in combination with R7 or R8 represents an alkylene, alone or in association with a pharmaceutically acceptable carrier. These compounds, which are usefull as intermediate and as bactericides, as antiviral agent and in the treatment of immunologic disoders.
Inventors:
Abi Abdelkrin
Gravel dennis
Villeneuve Brew
Su Hung Shen
Baylan Cool Marc
Gravel dennis
Villeneuve Brew
Su Hung Shen
Baylan Cool Marc
Application Number:
JP2002577810A
Publication Date:
March 09, 2011
Filing Date:
March 27, 2002
Export Citation:
Assignee:
Selmed Biosciences, Inc.
International Classes:
C07D311/82; A61K31/352; A61N5/06; A61P31/00; A61P31/04; A61P31/12; A61P35/00; A61P35/02; A61P37/00; C07D493/10
Domestic Patent References:
| JP63503071A | ||||
| JP61288872A | ||||
| JP10505349A | ||||
| JP2003510372A |
Foreign References:
| WO1999015517A1 | ||||
| WO1997009043A1 |
Other References:
PHOTOCHEMISTRY AND PHOTOBIOLOGY, vol. 63, no. 2, 1996, p161-168
Biotechnol.Appl.Biochem.(1999),30,1,p1-17
Biotechnol.Appl.Biochem.(1999),30,1,p1-17
Attorney, Agent or Firm:
Hatsushi Shimizu