Title:
免疫調節物質および抗癌剤としてのハロゲン化トリプトライド誘導体
Document Type and Number:
Japanese Patent JP4647587
Kind Code:
B2
Abstract:
Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, CR1R2 is selected from CHOH, C-O, CHF, CF2 and C(CF3)OH; CR6 and CR13 are selected from CH, COH and CF; CR7R8, CR9R10 and CR11R12 are selected from CH2, CHOH, C-O, CHF and CF2; and CR3R4R5 is selected from CH3, CH2OH, C-O, COOH, CH2F, CHF2 and CF3; such that: at least one of R1-R13 comprises fluorine; no more than two of CR3R4R5, CR6, CR7R8, CR9R10, CR11R12, and CR13 comprises fluorine or oxygen; and, when CR1R2 is CHOH, CR3R4R5 is not CH2F.
Inventors:
Dai, Dong Chen
Masser, John H.
Masser, John H.
Application Number:
JP2006503870A
Publication Date:
March 09, 2011
Filing Date:
February 25, 2004
Export Citation:
Assignee:
Pharma Genesis, Incorporated
International Classes:
C07D493/22; A61K31/34; A61K31/343; A61K31/36; A61K31/365; A61P35/00; A61P37/06; A61P37/08; A61P43/00; C07D307/77; C07D407/00; C07D491/14; C07D493/14; A61K
Domestic Patent References:
| JP2001504437A | ||||
| JP2001525851A | ||||
| JP3178977A |
Foreign References:
| WO2002056835A1 | ||||
| CN1052859A |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita