Title:
抗ミエリン関連糖タンパク質(MAG)抗体の治療での使用
Document Type and Number:
Japanese Patent JP4648895
Kind Code:
B2
Abstract:
A method for identifying an anti-MAG antibody or functional fragment thereof which is capable of treating neurological disease comprising the steps of
a) differentiating oligodendrocyte precursor cells in vitro,
b) treating said oligodendrocyte cells with glutamate in a cysteine-free medium,
c) adding test antibody or functional fragment thereof, or negative control IgG antibody,
d) assessing cell survival, and
e) comparing the level of cell survival obtained after the addition of the test antibody or functional fragment thereof with the level of cell survival obtained after the addition of a negative control IgG antibody.
Inventors:
Vinson, Mary
Irving, Elaine, Allison
Irving, Elaine, Allison
Application Number:
JP2006504411A
Publication Date:
March 09, 2011
Filing Date:
February 02, 2004
Export Citation:
Assignee:
GLAXO GROUP LIMITED
International Classes:
A61K39/395; A61P25/00; A61P25/14; A61P25/16; A61P25/28; C07K16/28; C12N15/09
Foreign References:
| WO2002062383A1 |
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Ishii Teiji
Satoshi Fujita