Title:
PSCAタンパク質に結合する抗体および関連分子
Document Type and Number:
Japanese Patent JP4651663
Kind Code:
B2
Abstract:
Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table 1. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
Inventors:
Gene Gudas
Jakovowitz, Aya
Jar, Xiao Chi
Morrison, Robert Kendal
Karen Jane Meyrick, Morrison
Xiao, Hui
Charita-Aid, Pia Em.
Liteano, Arthur Bee.
Jakovowitz, Aya
Jar, Xiao Chi
Morrison, Robert Kendal
Karen Jane Meyrick, Morrison
Xiao, Hui
Charita-Aid, Pia Em.
Liteano, Arthur Bee.
Application Number:
JP2007515180A
Publication Date:
March 16, 2011
Filing Date:
May 17, 2005
Export Citation:
Assignee:
Agensis, Inc.
International Classes:
C12N15/09; A61K39/395; A61P35/00; C07H21/04; C07K14/705; C07K16/30; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/06; C12P21/08; C12Q1/68; G01N33/15; G01N33/50; G01N33/574; A61K39/00
Foreign References:
| US20040018571 | ||||
| WO2001040309A1 | ||||
| EP1514876A1 | ||||
| US6258939 |
Other References:
Cancer Research,2002, Vol.62, pp.2546-2553
GU,ONCOGENE,2000年 3月,V19,P1288-1296
SAFFRAN,PNAS,2001年 2月27日,V98 N5,P2658-2663
GU,ONCOGENE,2000年 3月,V19,P1288-1296
SAFFRAN,PNAS,2001年 2月27日,V98 N5,P2658-2663
Attorney, Agent or Firm:
Kato Asamichi
Kiuchi Uchida
Kiuchi Uchida