Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
3-クロロメチル-3-セフェム誘導体の製造方法
Document Type and Number:
Japanese Patent JP4658806
Kind Code:
B2
Abstract:
An industrially advantageous process for producing 3-chloromethyl-3-cephem derivative crystals. The process for 3-chloromethyl-3-cephem derivative production comprises: a first step in which a thiazolineazetidinone derivative (1) is reacted with a sulfonyl halide (2) in the presence of an acid in a solvent to obtain an azetidinone derivative (3); a second step in which the azetidinone derivative (3) is reacted with a chlorinating agent in an organic solvent to obtain a chlorinated azetidinone derivative (4); and a third step in which the chlorinated azetidinone derivative (4) is reacted with an alcoholate (5) at a pH of 8 or lower in a solvent comprising an alcohol and an ether and a 3-chloromethyl-3-cephem derivative (6) is recovered in the form of crystals.

Inventors:
Nobuo Matsumoto
Hiroshi Kawabe
Yasuko Manabe
Application Number:
JP2005513859A
Publication Date:
March 23, 2011
Filing Date:
September 06, 2004
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
Nippon Chemical Industry Co., Ltd.
International Classes:
C07D501/24; C07D501/08; C07D501/10
Domestic Patent References:
JP3537050B22004-06-14
JPH0578371A1993-03-30
JPH03120288A1991-05-22
JPS5874689A1983-05-06
Foreign References:
WO2004039813A12004-05-13