Title:
抗血小板自己抗体およびそのインヒビターに関連する組成物、方法およびキット
Document Type and Number:
Japanese Patent JP4660189
Kind Code:
B2
Abstract:
The present invention relates to novel methods of identifying and producing an anti-platelet autoantibody. More preferably, the invention relates to identification and production of a human monoclonal anti-platelet autoantibody. Moreover, the invention relates to methods for treating or alleviating a disease, disorder or condition mediated by an anti-platelet autoantibody specifically binding with a platelet, or a component thereof, such as, but not limited to, idiopathic thrombocytopenic purpura, among others. Preferably, the antibody is an unglycosylated H44L4 Fab.
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Inventors:
Siegel, Donald El
Application Number:
JP2004520006A
Publication Date:
March 30, 2011
Filing Date:
July 03, 2003
Export Citation:
Assignee:
The Trustees of the University of Pennsylvania
International Classes:
C12N15/09; C07K16/00; C07K16/28; C07K16/42; C07K16/46; C12N15/13; C12P21/08; C12Q1/70; G01N33/15; G01N33/53; G01N33/567; G01N33/68; G01N33/86; A61K39/395; A61P7/02
Domestic Patent References:
| JP4501503A | ||||
| JP2002529054A | ||||
| JP11180894A |
Other References:
British Journal of Haematology,2002, Vol.116, pp.677-685
Journal of Immunology, 2002, Vol.168, pp.2035-2045
Blood,1997, Vol.89, No.11, pp.4078-4084
Blood,1992, Vol.79, No.2, pp.447-451
Journal of Immunology, 2002, Vol.168, pp.2035-2045
Blood,1997, Vol.89, No.11, pp.4078-4084
Blood,1992, Vol.79, No.2, pp.447-451
Attorney, Agent or Firm:
Patent business corporation Odashima patent office