Title:
ヒト胚幹細胞由来の膵島細胞
Document Type and Number:
Japanese Patent JP4666567
Kind Code:
B2
Abstract:
This disclosure provides a system for producing pancreatic islet cells from embryonic stem cells. Differentiation is initiated towards endoderm cells, and focused using reagents that promote emergence of islet precursors and mature insulin-secreting cells. High quality populations of islet cells can be produced in commercial quantities for use in research, drug screening, or regenerative medicine.
Inventors:
Fisk Gregory Jay.
Inokuma Margaret S.
Inokuma Margaret S.
Application Number:
JP2003551271A
Publication Date:
April 06, 2011
Filing Date:
December 06, 2002
Export Citation:
Assignee:
GERON CORPORATION
International Classes:
C12N5/073; A01N63/00; A01N65/00; A61K48/00; C12M3/00; C12N5/00; C12N5/02; C12N5/071; C12N5/074; C12N15/17; C12N15/18; C12N15/85; A61K35/12
Other References:
Diabetes, vol.50, pp.1691-1697 (Aug.2001)
Diabetologia, vol.44, pp.407-415 (Apr.2001)
Diabetes, vol.49, pp.1-6 (2000)
Exp.Cell Res., vol.247, pp.241-248 (1999)
Proc.Natl.Acad.Sci.USA., vol.97(1), pp.11307-11312 (2000)
Exp.Cell Res., vol.192, pp.46-51 (1991)
Exp.Cell Res., vol.217, pp.22-30 (1995)
G.I.Research, vol.7(4), pp.239-247 (1999)
Exp.Cell Res., vol.229, pp.27-34 (1996)
日本獣医学会学術集会講演要旨集, vol.129th, p.30, A-27 (2000)
Diabetologia, vol.44, pp.407-415 (Apr.2001)
Diabetes, vol.49, pp.1-6 (2000)
Exp.Cell Res., vol.247, pp.241-248 (1999)
Proc.Natl.Acad.Sci.USA., vol.97(1), pp.11307-11312 (2000)
Exp.Cell Res., vol.192, pp.46-51 (1991)
Exp.Cell Res., vol.217, pp.22-30 (1995)
G.I.Research, vol.7(4), pp.239-247 (1999)
Exp.Cell Res., vol.229, pp.27-34 (1996)
日本獣医学会学術集会講演要旨集, vol.129th, p.30, A-27 (2000)
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Kazuya Kawamoto
Toshi Gobe
Koichi Niimi
Kazuya Kawamoto