Title:
炎症性疾患治療用フタラジン誘導体
Document Type and Number:
Japanese Patent JP4673977
Kind Code:
B2
Abstract:
The invention relates to the treatment of leukemias with an inhibitor of the activity of VEGF receptor tyrosine kinase of the formula I, the substituents being defined in the specification; as well as to new phthalazine derivatives; processes for the preparation thereof; the application thereof in a process for the treatment of the human or animal body; the use thereof for the treatment of a disease, especially a disease caused by ocular neovascularization, such as age-related macula degeneration or diabetic retinopathy, or other diseases that respond to the inhibition of tyrosine kinases, such as a proliferative disease; a method for the treatment of such disease in mammals; and the use of such a compound for the manufacture of a pharmaceutical preparation for the treatment especially of a disease as mentioned above.
Inventors:
Guido Bolt
Janet Dawson King
Jörg Fry
Richard Ang
Paul William Manly
Bernhard Beatfelt
Janet Marjorie Wood
Janet Dawson King
Jörg Fry
Richard Ang
Paul William Manly
Bernhard Beatfelt
Janet Marjorie Wood
Application Number:
JP2000609072A
Publication Date:
April 20, 2011
Filing Date:
March 28, 2000
Export Citation:
Assignee:
Novartis Age
International Classes:
C07D401/06; A61K31/502; A61K31/506; A61P1/16; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P9/14; A61P13/12; A61P17/06; A61P19/02; A61P25/04; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P35/02; A61P37/00; A61P43/00; C07D401/14
Domestic Patent References:
| JP8225541A | ||||
| JP1261386A | ||||
| JP10218791A | ||||
| JP10087481A | ||||
| JP2002522475A |
Foreign References:
| WO1998035958A1 |
Other References:
SHEPPARD,C.L. et al.,Polynuclear copper(II) complexes with μ2-1,1-azide bridges. Structural and magnetic properties,Inorganica Chimica Acta,1996年,Vol.250, No.1-2,p.227-239
CHEN,L. et al.,Dinuclear and tetranuclear copper(II) complexes of the tetradentate ligand 1,4-bis(2-pyridylthio)phthalazine: structural, magnetic, and electrochemical studies,Inorganic Chemistry,1993年,Vol.32, No.13,p.2938-2943
C.G.WERMUTH 編, 長瀬博 監訳,最新 創薬化学 上巻,株式会社 テクノミック,1998年,p.243
CHEN,L. et al.,Dinuclear and tetranuclear copper(II) complexes of the tetradentate ligand 1,4-bis(2-pyridylthio)phthalazine: structural, magnetic, and electrochemical studies,Inorganic Chemistry,1993年,Vol.32, No.13,p.2938-2943
C.G.WERMUTH 編, 長瀬博 監訳,最新 創薬化学 上巻,株式会社 テクノミック,1998年,p.243
Attorney, Agent or Firm:
Aoyama Aoi
Kazuaki Kojima
Mitsutaka Iwasaki
Kazuaki Kojima
Mitsutaka Iwasaki