Title:
結晶性粒子の新規製造装置および製造法
Document Type and Number:
Japanese Patent JP4700247
Kind Code:
B2
Abstract:
An apparatus for preparing crystalline particles of a substance suitable for inhalation therapy comprises (i) a first reservoir 3 of said substance dissolved in a liquid solvent; (ii) a second reservoir 3 of liquid antisolvent for said substance which is miscible with the liquid solvent; (iii) a cylindrical mixing chamber 2 having first and second tangential inlet ports and an axial outlet port; (iv) means for delivering the contents of the first and second reservoirs to the mixing chamber in a stream via the first and second inlet ports respectively at independent controlled flow rate, the streams of liquid from t he i nlet a nd o utlet ports being intimately mixed in the cylindrical mixing chamber through formation of a vortex thereby causing precipitation of crystalline particles of the substance; and (vi) means 5 for collecting crystalline particles suspended in the stream of liquid discharged from the outlet port of the mixing chamber.
Inventors:
Alan Ronald Ferry
Andrew Patrick The Budge
Andrew Patrick The Budge
Application Number:
JP2001534333A
Publication Date:
June 15, 2011
Filing Date:
November 03, 2000
Export Citation:
Assignee:
GLAXO GROUP LIMITED
International Classes:
A61J3/02; A61J1/00; A61K9/00; A61K9/12; A61K9/14; A61K9/16; A61K9/72; A61K31/135; A61K31/56; A61K31/573; A61K47/06; A61K47/26; A61M13/00; B01D9/00; B01F5/00; B01F3/08; A61J
Domestic Patent References:
| JP3005483A | ||||
| JP62027032A |
Foreign References:
| WO1998013031A2 | ||||
| US4826589 |
Attorney, Agent or Firm:
Aoyama Aoi
Mitsuo Tanaka
Mitsuo Tanaka