Title:
プロテインキナーゼB阻害剤としてのピロロ[2,3-D]ピリミジン誘導体
Document Type and Number:
Japanese Patent JP4705695
Kind Code:
B2
Abstract:
The invention relates to a novel group of compounds of Formula (I) or salts thereof:wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I).
Inventors:
Johnson, Paul David
Reach, Andrew
Luke, Richard William Arthur
Zutigh New Stanley, Matusiak
Morris, Jeffrey James
Reach, Andrew
Luke, Richard William Arthur
Zutigh New Stanley, Matusiak
Morris, Jeffrey James
Application Number:
JP2010528485A
Publication Date:
June 22, 2011
Filing Date:
October 09, 2008
Export Citation:
Assignee:
AstraZeneca Activrag
International Classes:
C07D487/04; A61K31/519; A61P35/00; A61P43/00; C07D211/66; A61K31/52; A61K31/5377; C07D473/32
Domestic Patent References:
| JP2009534456A | ||||
| JP2004532234A |
Foreign References:
| WO2006046024A1 | ||||
| WO2006046023A1 | ||||
| WO2005095386A1 |
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Akiko Nakahama
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Akiko Nakahama