急性および慢性炎症、虚血およびリモデリング過程に対する治療剤としてのピリミジノン誘導体

Title:

急性および慢性炎症、虚血およびリモデリング過程に対する治療剤としてのピリミジノン誘導体

Document Type and Number:

Japanese Patent JP4708034

Kind Code:

B2

Abstract:

Compounds of formula (I) and salts, hydrates and/or solvates thereof and their tautomeric forms in which A is an aryl or heteroaryl ring, each of R<1>, R<2> and R<3> are independently H or various substituents, R<4>, R<5>, R<6> and R<7> are various substituents and each of Y<1>, Y<2> Y<3>, Y<4>, and Y<5> are independently CH or N so that the ring contains 0, 1 or 2 nitrogen atoms. In particular, A is a phenyl ring, each of Y<1>-Y<5> is CH and R<4> is an alkoxycarbonyl residue. The compounds may be inhibitors of human leukocyte elastase (HLE, also known as human neutrophil elastase or HNE) and as such may be useful in the treatment of chronic obstructuive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.

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Inventors:

Heike Gillen-Hertwig
Volkhard Min-Jean Li
Ulrich Rosent Letter
Karl-Heinz Schlenmer
Sven Aller Heiligen
Lyra Terran
Lars Belfucker
Jörg Kerdenig
Mary F. Fitzgerald
Kevin Nash
Barbara Albrecht
Dirk Moyler

Application Number:

JP2004571738A

Publication Date:

June 22, 2011

Filing Date:

August 28, 2003

Export Citation:

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Assignee:

Bayer Schering Pharma Aktiengesellschaft

International Classes:

C07D239/22; A61K31/505; A61K31/506; A61K31/5377; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P29/00; A61P43/00; C07D401/04; C07D401/06; C07D401/12; C07D403/06; C07D403/12; C07D405/06; C07D405/12; C07D413/04; C07D413/12; C07D417/04; C07D417/12

Other References:

LEWANDOWSKI, K. et al,JOURNAL OF COMBINATORIAL CHEMISTRY,米国,AMERICAN CHEMICAL SOCIETY,1999年,V1 N1,P105-112
BARLUENGA J,HETEROCYCLES,1994年,V37 N2,P1109-1120
DANDIA A,JOURNAL OF FLUORINE CHEMISTRY,スイス,ELSEVIER SEQUOIA,1998年 6月26日,V90 N1,P17-21

Attorney, Agent or Firm:

Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Mitsutaka Iwasaki
Yasushi Ochiai

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