新規オキサゾリジノン誘導体 - Don A Farm Company Limited

Title:

新規オキサゾリジノン誘導体

Document Type and Number:

Japanese Patent JP4739229

Kind Code:

B2

Abstract:

The present invention relates to novel derivatives of oxazolidinone, a method thereof and pharmaceutical compositions comprising the derivatives for use in an antibiotic. The oxazolidinone derivatives of the present invention show inhibitory activity against a broad spectrum of bacteria and lower toxicity. The prodrugs, prepared by reacting the compound having hydroxyl group with amino acid or phosphate, have an excellent efficiency on solubility thereof against water. Further, the derivatives of the present invention may exert potent antibacterial activity versus various human and animal pathogens, including Gram-positive bacteria such as Staphylococi, Enterococci and Streptococi, anaerobic microorganisms such as Bacteroides and Clostridia, and acid-resistant microorganisms such as Mycobacterium tuberculosis and Mycobacterium avium. Accordingly, the compositions comprising the oxazolidinone are used in an antibiotic.

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Inventors:

Lee, jekeol
Im, wayon bin
Cho, Chun Fan
Choi, Sun Haku
Lee, Tahoe

Application Number:

JP2006545238A

Publication Date:

August 03, 2011

Filing Date:

December 17, 2004

Export Citation:

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Assignee:

Don A Farm Company Limited

International Classes:

C07D413/14; A61K31/4439; A61P31/04; C07D263/32; C07D417/10; C07D417/14; C07F9/653; C07F9/6558; A61K31/421; A61K31/427

Domestic Patent References:

JP2003535860A
JP57099576A
JP2124877A
JP2006515601A

Foreign References:

WO2003022824A1
WO2003072553A1

Other References:

監訳長瀬博,最新創薬化学,テクノミック,1999年 9月25日,下巻,p. 368-382
BAE, S, K.,High-performance liquid chromatographic analysis of DA-7867, a new oxazolidinone, in human plasma and urine and in rat tissue homogenates,Journal of Chromatography B,2003年,794(2),p. 397-403

Attorney, Agent or Firm:

Hiroshi Kobayashi
Eiji Katayama
Norio Omori
Mami Hino
Yasuhito Suzuki

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