Title:
合成抗体ファージライブラリー
Document Type and Number:
Japanese Patent JP4753578
Kind Code:
B2
Abstract:
The invention provides comprising variant amino acids in CDRs of antibody variable domains. These polypeptides provide a source of great sequence diversity that can be used as a source for identifying novel antigen binding polypeptides. The invention also provides these polypeptides as fusion polypeptides to heterologous polypeptides such as at least a portion of phage or viral coat proteins, tags, and linkers. Libraries comprising a plurality of these polypeptides are also provided. In addition, methods of and compositions for generating and using these polypeptides and libraries are provided.
Inventors:
Who, Jermain, Gee.
Sidu, Sachidev, Es.
Sidu, Sachidev, Es.
Application Number:
JP2004510399A
Publication Date:
August 24, 2011
Filing Date:
June 03, 2003
Export Citation:
Assignee:
Genentech, Incorporated
International Classes:
C12N15/09; G01N33/53; C07K16/00; C07K16/22; C07K16/32; C07K16/42; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/00; C40B40/08; C40B40/10
Other References:
J. Mol. Biol., vol. 248, pages 97-105 (1995)
EMBO J. vol. 13, pages 3245-3260 (1994)
EMBO J. vol. 13, pages 692-698 (1994)
J. Mol. Biol., vol. 296, pages 57-86 (2000)
J. Mol. Biol., vol. 338, pages 299-310 (2004)
J. Mol. Biol., vol. 340, pages 1073-1093 (2004)
J. Immunol. Methods, vol. 284, pages 119-132 (2004)
EMBO J. vol. 13, pages 3245-3260 (1994)
EMBO J. vol. 13, pages 692-698 (1994)
J. Mol. Biol., vol. 296, pages 57-86 (2000)
J. Mol. Biol., vol. 338, pages 299-310 (2004)
J. Mol. Biol., vol. 340, pages 1073-1093 (2004)
J. Immunol. Methods, vol. 284, pages 119-132 (2004)
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori