Title:
ペプチドの水溶性及び金属標識効率を改善した医療用組成物及び該ペプチドが金属標識された医療用製剤
Document Type and Number:
Japanese Patent JP4759508
Kind Code:
B2
Abstract:
By preliminarily dissolving a basic organic compound in an aqueous solvent in which a peptide usable in metal-labeling is to be dissolved, the solubility of the peptide is improved and thus metal-labeling can be carried out without heating. A composition for medical use containing a peptide usable in metal-labeling and a basic organic compound acceptable as a pharmaceutical additive can be utilized as a preparation useful in image diagnosis, radiotherapy and so on.
Inventors:
Kawaguchi
Ikuya Seki
Maemura Marino
Ikuya Seki
Maemura Marino
Application Number:
JP2006511467A
Publication Date:
August 31, 2011
Filing Date:
March 23, 2005
Export Citation:
Assignee:
Nihon Medi-Physics Co., Ltd.
International Classes:
A61K38/00; A61K9/08; A61K47/18; A61K47/22; A61K47/46; A61K49/00; A61K51/00; A61K51/08; A61K51/12; A61P35/00; C07K1/13
Other References:
VERBEKE,K. et al,Influence of the bifunctional chelate on the biological behavior of (99m)Tc-labeled chemotactic peptide conjugates,Nucl Med Biol,2000年,Vol.27, No.8,p.769-79
BEHR,T.M. et al,Reduction of the renal uptake of radiolabeled monoclonal antibody fragments by cationic amino acids and their derivatives,Cancer Res,1995年,Vol.55, No.17,p.3825-34
BEHR,T.M. et al,Reduction of the renal uptake of radiolabeled monoclonal antibody fragments by cationic amino acids and their derivatives,Cancer Res,1995年,Vol.55, No.17,p.3825-34
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Makoto Koike
Katsunori Ando
Hajime Asamura
Makoto Koike
Katsunori Ando