Title:
副甲状腺ホルモンのレセプターとそれをコードしているDNA
Document Type and Number:
Japanese Patent JP4790836
Kind Code:
B2
Abstract:
An antagonist or agonist compound for use in the treatment of hypercalcemia or hypocalcemia. The compound is identifiable as being a compound capable of competing with a parathyroid hormone or parathyroid hormone-related protein for binding to a parathyroid hormone receptor. Identification is carried out by contacting a polypeptide with a parathyroid hormone or parathyroid hormone-related protein in the presence or absence of a candidate compound. The polypeptide comprises at least six amino acids and less than the complete amino acid sequence of a parathyroid hormone receptor having an amino acid sequence with at least 30% identity to the amino acid sequence shown in SEQ. ID NO. 3.
Inventors:
Segre Guinobu
Kronenberg Henry M
Abou Samla Abdul Buddy
Japner Harald
Potts Joan Tay Junior
Sipani Arnestina
Kronenberg Henry M
Abou Samla Abdul Buddy
Japner Harald
Potts Joan Tay Junior
Sipani Arnestina
Application Number:
JP2009188644A
Publication Date:
October 12, 2011
Filing Date:
August 17, 2009
Export Citation:
Assignee:
The General Hospital Corporation
International Classes:
A01K67/027; A61K38/00; C12N15/09; A61K39/00; A61K39/395; A61P3/00; A61P3/02; A61P3/14; A61P5/12; C07K5/00; C07K7/04; C07K7/06; C07K7/08; C07K14/435; C07K14/635; C07K14/705; C07K14/72; C07K16/00; C07K16/28; C12N1/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/113; C12N15/12; C12N15/85; C12P21/02; C12P21/08; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/566; G01N33/68; G01N33/78; G01N33/84; C12R1/91
Domestic Patent References:
| JP6506598A |
Other References:
Proc Natl Acad Sci USA, vol.89, p.2732-2736 (1992.4.1)
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Kazuya Kawamoto
Toshi Gobe
Koichi Niimi
Kazuya Kawamoto