Title:
ヒアルロン酸誘導体及びそれを含む薬剤
Document Type and Number:
Japanese Patent JP4792294
Kind Code:
B2
Abstract:
The present invention relates to a hyaluronic acid derivative in which an anti-inflammatory drug is bound via a covalent bond, wherein the structure of the hyaluronic acid derivative is represented by following formula (4) or (5):
HA-SP-NSAID(4)
HA-SP-DMARD(5)
wherein HA represents a hyaluronic acid chain; SP represents a spacer residue; NSAID represents a non-steroidal anti-inflammatory drug residue, DMARD represents a disease-modifying anti-rheumatic drug residue, and - represents the covalent bond, wherein the spacer binds to a carboxyl group of the hyaluronic acid via an amide bond and the anti-inflammatory drug selected from non-steroidal anti-inflammatory drugs and disease-modifying anti-rheumatic drugs binds to the spacer via an ester bond, an amide bond or a thioester bond.
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Inventors:
Kenji Miyamoto
Yosuke Yasuda
Keiji Yoshioka
Yosuke Yasuda
Keiji Yoshioka
Application Number:
JP2005516899A
Publication Date:
October 12, 2011
Filing Date:
January 07, 2005
Export Citation:
Assignee:
Seikagaku Corporation
International Classes:
A61K47/36; A61K9/08; A61K31/192; A61K31/196; A61K31/405; A61K31/5415; A61K31/60; A61K31/728; A61K45/00; A61K47/18; A61K47/48; A61P19/02; A61P29/00; A61P29/02; C07C219/10; C08B37/08; A61K31/407; A61K31/616
Domestic Patent References:
| JPS6264802A | 1987-03-23 | |||
| JPS63105003A | 1988-05-10 | |||
| JPH09188705A | 1997-07-22 | |||
| JPH0672893A | 1994-03-15 | |||
| JPH0388802A | 1991-04-15 | |||
| JP2002249501A | 2002-09-06 | |||
| JPH09136902A | 1997-05-27 |
Foreign References:
| WO1999059603A1 | 1999-11-25 | |||
| WO1992006714A1 | 1992-04-30 | |||
| WO2002009792A1 | 2002-02-07 | |||
| WO1996035721A1 | 1996-11-14 | |||
| WO2002000167A2 | 2002-01-03 |
Attorney, Agent or Firm:
Norio Saeki