Title:
肺疾患の防止および診断のための表面活性剤タンパク質D
Document Type and Number:
Japanese Patent JP4807902
Kind Code:
B2
Abstract:
Surfactant protein D (SP-D) is a 43-kDa member of the collectin family of collagenous lectin domain-containing proteins that is expressed in epithelial cells of the lung. The SP-D gene was targeted by homologous recombination in embryonic stem cells that were used to produce SP-D (-/-) mice. The SP-D (-/-) deficiency caused inflammation, increased oxidant production by isolated alveolar macrophages, abnormal surfactant structure and levels, and decreased SP-A expression. Therefore, disclosed is the SP-D (-/-) mouse as an excellent model for emphysema. Also included are models for testing emphysema therapies in the mouse model, methods for using SP-D protein or DNA as a treatment for emphysema and pulmonary infections, and diagnosis.
Inventors:
Whitet, Jeffery A.
Application Number:
JP2000577281A
Publication Date:
November 02, 2011
Filing Date:
October 20, 1999
Export Citation:
Assignee:
Children's Hospital Medical Center
International Classes:
A01K67/027; A61K9/12; A61K35/76; A61K38/00; A61K48/00; A61P11/00; C07K14/47; C07K14/785; C07K16/18; C12N15/09; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/566
Domestic Patent References:
| JPH09500782A | 1997-01-28 |
Attorney, Agent or Firm:
Yoshiyuki Kawaguchi
Hidemi Matsukura
Hidemi Matsukura