Title:
改良されたエレクトロスプレー及び他のLC/MSインターフェース
Document Type and Number:
Japanese Patent JP4812219
Kind Code:
B2
Abstract:
An improved method and apparatus for performing Mass spectrometry, in particular, Liquid chromatography/Mass spectrometry (LC/MS) is disclosed. Controlled generation of individual charged droplets enables the subsequent steps of trapping, desolvation and concentration. Miniaturization is also enabled. In contrast, conventional means of forming Electrosprays are chaotic, generating large numbers of charged droplets simultaneously. Additional flows of gas are provided in a nebulization region to effectively remove undesired solvent vapor and concentrate desirable analyte containing droplets and/or analyte ions. A semipermeable structure is used to effectively separate associated gas flow streams. Ions are concentrated or trapped using electrodes which are bound in the nebulization region and are appropriately electrically biased so as to concentrate the ions on one side, or in the center, or in a ring of the laminar gas stream. Additionally, a valve may be used to interrupt the flow gas into a detector region.
More Like This:
Inventors:
Jarrell, Joseph A.
Strand, David M
Strand, David M
Application Number:
JP2001577582A
Publication Date:
November 09, 2011
Filing Date:
April 18, 2001
Export Citation:
Assignee:
Waters Technologies Corporation
International Classes:
G01N27/62; H01J49/10; G01N30/72; H01J49/04; H01J49/42
Domestic Patent References:
| JPH0650940A | 1994-02-25 | |||
| JPH09189681A | 1997-07-22 | |||
| JP2000067806A | 2000-03-03 | |||
| JPH0413962A | 1992-01-17 | |||
| JPH06102245A | 1994-04-15 |
Foreign References:
| US5838002A | 1998-11-17 |
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Kazuo Shamoto
Shogo Nakamura
Tadashi Masui
Hideo Tanaka
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Kazuo Shamoto
Shogo Nakamura
Tadashi Masui
Hideo Tanaka